We consider cancer belle de grasse cytotoxic drugs as an optimal control problem to stabilize a heterogeneous tumor by attacking not the most abundant cancer cells, but those that are crucial in the tumor ecosystem.We propose a mathematical cancer stem cell model that translates the hierarchy and heterogeneity of cancer cell types by including high
The paper presents the results of detailed structural analysis of the Dzhankhot thrust zone which is a part of the system of overthrust nappe structures in the southern slope of the Northwestern Caucasus.The relevance of the research topic is found on the reason that despite the obvious importance of these overthrust nappes in the structure of the
Goal: The paper aims to investigate the insights of the resilience mechanisms of Brazilian small farms facing COVID-19.Design / Methodology / Approach: The research path involves three cases studies: two small but relevant producers of fruit and vegetable and a 3 gallon flat back bucket cooperative of family farmers in Rio de Janeiro through semi-s
The purpose of this study was to find out an overview of an innovation learning model in the form of the application of the Contextual Approach applied to the Scaffolding Learning Model.This innovation is a creativity that is carried out in classroom learning to create a combination of an approach buffalo bills big chain necklace and a learning mod
The present study deals with initial formation of concept of decimal system in second year of education at primary school in Mexico (City of Puebla).Our research is based on Activity Theory conception of teaching-learning process and of gradual introduction of scientific concepts in school age.The method has been designed and worked out with the he